Editor’s Highlight: Ethylene Glycol Teratogenicity: A Role for Embryonic Acidosis?
نویسندگان
چکیده
منابع مشابه
Ethylene glycol induces hyperoxaluria without metabolic acidosis in rats.
Ethylene glycol (EG) consumption is commonly employed as an experimental regimen to induce hyperoxaluria in animal models of calcium oxalate nephrolithiasis. This approach has, however, been criticized because EG overdose induces metabolic acidosis in humans. We tested the hypothesis that EG consumption (0.75% in drinking water for 4 wk) induces metabolic acidosis by comparing arterial blood ga...
متن کاملEthylene glycol poisoning: a rare but life-threatening cause of metabolic acidosis—a single-centre experience
BACKGROUND Intoxication with ethylene glycol happen all around the world and without rapid recognition and early treatment, mortality from this is high. METHODS In our study, we retrospectively analysed six cases of ethylene glycol intoxication in our department. We measured ethylene glycol or glycolate levels, lactate levels and calculated the osmolal and anion gap. RESULTS Data from six p...
متن کاملScreening Assay for Ethylene Glycol
To the Editor: The recent paper by Eder et al. (1) recalls, among other things, the problems that a clinical STAT laboratory has to face in the case of ethylene glycol poisoning. As an alternative to the precise and accurate gas chromatographic technique, the enzymatic assay with glycerol dehydrogenase (EC 1.1.1.6) and NADH as tracer has been proposed by various authors [see, e.g., (2–4)]. The ...
متن کاملpropylene glycol , and ethylene glycol - based antifreeze
of AF performance. that contain EG has been reponed to result in irreversible damage to renal, hepatic, cardiovascular, and central nervous systems, and is a cause of death in household pets and other animals.2-4 It is not known why some animals ingest EGcontaining products. Although there are reports suggesting that the "sweet" taste of EG, and of products containing it, may lead to ingestion ...
متن کاملFatal Ethylene Glycol Intoxication
Clinical and forensic laboratories frequently have to face cases of severe intoxication from ethylene glycol, because of its wide availability, and thus its use as an additive in various housekeeping and commercial products such as anti-freezing agent, car batteries and solvents for dyes. The majority of ethylene glycol poisonings is related to suicide attempts (intentional ingestion) and to mi...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2017
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfx225